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May increase dose in increments of 1 tab of 250 mg/1.25 mg/day every 2 wk or longer according to glycemia results. 2nd-line therapy Initially 1 tab of 500 mg/2.5 mg or 500 mg/5 mg once daily. Initial dose must not exceed the daily doses of glibenclamide (or equiv dose of another sulfonylurea) or metformin already being taken. skema inverter 500 watt